Targeting the glucocorticoid receptor in breast and prostate cancers.

Abstract

Steroid receptors for androgens and estrogens have essential roles in prostate and breast cancers. Recently, glucocorticoid receptor (GR) activity has also been proposed as having an important role in these cancers. Underscoring the cooperative nature of nuclear receptor activity, data now suggest that GR function in prostate and breast cancers is dependent on the tumor's concomitant androgen or estrogen receptor activity.

• Authors: Jacob Kach, Suzanne D Conzen, Russell Z Szmulewitz
• Journal: Science translational medicine (Sci Transl Med) Vol. 7 Issue 305 Pg. 305ps19 (Sep 16 2015) ISSN: 1946-6242 [Electronic] United States
• PMID: 26378243 (Publication Type: Journal Article)
• Copyright: Copyright © 2015, American Association for the Advancement of Science.

Chemical References

• AR protein, human
• ESR1 protein, human
• Estrogen Receptor alpha
• Receptors, Androgen
• Receptors, Glucocorticoid

Topics

• Animals
• Breast Neoplasms (drug therapy, metabolism)
• Cell Survival
• Estrogen Receptor alpha (metabolism)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Male
• Prognosis
• Prostatic Neoplasms (drug therapy, metabolism)
• Receptors, Androgen (metabolism)
• Receptors, Glucocorticoid (metabolism)
• Signal Transduction
• Translational Research, Biomedical