Brain tumor cells invade adjacent normal brain along white matter (WM) bundles of axons. We therefore hypothesized that the location of
tumor intersecting WM tracts would be associated with differing survival. This study introduces a method, voxel-wise survival analysis (VSA), to determine the relationship between the location of
brain tumor intersecting WM tracts and patient prognosis. 113 primary
glioblastoma (GBM) patients were retrospectively analyzed for this study. Patient specific
tumor location, defined by contrast-enhancement, was combined with diffusion tensor imaging derived tractography to determine the location of axons intersecting
tumor enhancement (AXITEs). VSA was then used to determine the relationship between the AXITE location and patient survival.
Tumors intersecting the right anterior thalamic radiation (ATR), right inferior fronto-occipital fasciculus (IFOF), right and left cortico-spinal tract (CST), and corpus callosum (CC) were associated with decreased overall survival.
Tumors intersecting the CST, body of the CC, right ATR, posterior IFOF, and inferior longitudinal fasciculus are associated with decreased progression-free survival (PFS), while
tumors intersecting the right genu of the CC and anterior IFOF are associated with increased PFS. Patients with
tumors intersecting the ATR, IFOF, CST, or CC had significantly improved survival prognosis if they were additionally treated with
bevacizumab. This study demonstrates the usefulness of VSA by locating AXITEs associated with poor prognosis in GBM patients. This information should be included in patient-physician conversations, therapeutic strategy, and clinical trial design.