[Synthesis and pharmacologic study of diethyl N-palmitoyl glutamate].

Abstract

The diethyl N-palmitoyl glutamate (DEEPGt) was synthesized by the mixed anhydrides method and pharmacologically studied; hypothermy, sedation, myorelaxation and antagonism of the pentetrazole (PTZ) convulsions were obtained in mice. The haloperidol catalepsy's potentiation coming with oral dyskinesias were observed on rats. It seems, in the light of this pharmacological exploration, that DEEPGt penetrates easily in the brain and develops an anti-glutamatergic activity. It is probably the slow liberation of N-palmitoyl glutamic acid (PGt) from the DEEPGt which amplifies its anti-PTZ activity and could be interesting against the memory impairing action of all the glutamatergic antagonists which are actually considered as the possible next generation of antiepileptic and neuroprotecting drugs.

• Authors: A Vamvakides, N Kolocouris
• Journal: Annales pharmaceutiques francaises (Ann Pharm Fr) Vol. 47 Issue 4 Pg. 205-12 ( 1989) ISSN: 0003-4509 [Print] France
• Vernacular Title: Synthèse et étude pharmacologique du diéthyl N-palmitoyl glutamate.
• PMID: 2637642 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anticonvulsants
• Glutamates
• Hypnotics and Sedatives
• diethyl N-palmitoylglutamate

Topics

• Animals
• Anticonvulsants
• Body Temperature (drug effects)
• Female
• Glutamates (chemical synthesis, pharmacology, toxicity)
• Hypnotics and Sedatives
• Male
• Mice
• Mice, Inbred BALB C
• Rats
• Rats, Inbred Strains