Abnormal Biochemical Analytes Used for Aneuploidy Screening and Adverse Pregnancy Outcomes in Twin Gestations.

Abstract

OBJECTIVE:

The objective of this study was to determine if first- and second-trimester biochemical markers for aneuploidy have an association with adverse pregnancy outcomes in twin gestations.

STUDY DESIGN:

A retrospective cohort study of patients who presented with dichorionic diamniotic twin gestations was performed. Patients with first-trimester low pregnancy-associated plasma protein A (PAPP-A) or low free β human chorionic gonadotropin (β-hCG), or second-trimester elevated α-fetoprotein (AFP), elevated inhibin A, elevated hCG, or low unconjugated estradiol were identified. The rates of adverse pregnancy outcomes were compared between patients with or without abnormal analytes with p < 0.05 used as significance.

RESULTS:

In this study, 340 pregnancies were included. Patients with a low PAPP-A had an increased risk for delivery < 37 weeks. Patients with an elevated second-trimester hCG had an increased risk for spontaneous delivery < 28 weeks and neonatal intensive care unit (NICU) admission. Patients with an elevated inhibin A had an increased risk of spontaneous delivery at < 37 and NICU admission. Patients with an elevated AFP had an increased risk of a NICU admission.

CONCLUSION:

Certain abnormal aneuploidy markers are associated with an increased risk of adverse pregnancy outcomes in twin gestations.

• Authors: Jonathan Y Rosner, Nathan S Fox, Daniel Saltzman, Chad K Klauser, Andrei Rebarber, Simi Gupta
• Journal: American journal of perinatology (Am J Perinatol) Vol. 32 Issue 14 Pg. 1331-5 (Dec 2015) ISSN: 1098-8785 [Electronic] United States
• PMID: 26375045 (Publication Type: Journal Article)
• Copyright: Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Chemical References

• Biomarkers
• Chorionic Gonadotropin, beta Subunit, Human
• alpha-Fetoproteins
• inhibin A
• Estradiol
• Inhibins
• Pregnancy-Associated Plasma Protein-A

Topics

• Adult
• Aneuploidy
• Biomarkers (blood)
• Chorionic Gonadotropin, beta Subunit, Human (blood)
• Estradiol (blood)
• Female
• Humans
• Inhibins (blood)
• Intensive Care, Neonatal
• Pregnancy
• Pregnancy Trimester, First (blood)
• Pregnancy Trimester, Second (blood)
• Pregnancy, Twin
• Pregnancy-Associated Plasma Protein-A (metabolism)
• Premature Birth (blood)
• Prenatal Diagnosis
• Retrospective Studies
• alpha-Fetoproteins (metabolism)