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Immunomodulatory Effect of β-Glucan on Peritoneal Macrophages of Bab1/c Mice.

Abstract
We assessed the effect of β-Glucan on macrophages by Griess reagent and viability by MTT assay and cytotoxicity. Assay of macrophages culture supernatants were carried out on WEHI-164 fibrosarcoma cell line as tumor necrosis factor-α bioassay were done. NO release was increased at the dose of 10 µg/ml (P = 0.001) of β-Glucan while the viability of macrophages in all concentrations was the same. In TNF-α bioassay, the supernatant of macrophages stimulated with β-Glucan had a significant cytotoxic effect on WEHI-164 cells (P = 0.023). β-Glucan had a positive effect on increasing tumoricidal activity of macrophages which may help in anti-cancer immune responses.
AuthorsMaryam Roudbary, Saeed Daneshmand, Monire Hajimorad, Shahla Roudbarmohammadip, Zuhair M Hassan
JournalPolish journal of microbiology (Pol J Microbiol) Vol. 64 Issue 2 Pg. 175-9 ( 2015) ISSN: 1733-1331 [Print] Poland
PMID26373179 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • beta-Glucans
Topics
  • Animals
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Female
  • Macrophages, Peritoneal (drug effects)
  • Mice
  • Mice, Inbred BALB C
  • beta-Glucans (pharmacology)

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