Immune Reconstitution Inflammatory Syndrome Secondary to Mycobacterium kansasii Infection in a Kidney Transplant Recipient.

Abstract

Nontuberculous mycobacteria (NTM) infection is a challenging diagnosis for clinicians in solid organ transplantation. Immune reconstitution inflammatory syndrome (IRIS) is so far unreported in this context. We report here the case of a renal transplant recipient who developed Mycobacterium kansasii-associated lymphadenitis complicated by IRIS while undergoing reduction of his immunosuppressive therapy. For IRIS, the patient required low-dose steroids and an increase in global immunosuppression, in association with NTM antibiotherapy.

• Authors: M Lemoine, C Laurent, M Hanoy, J Leporrier, A François, D Guerrot, M Godin, D Bertrand
• Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (Am J Transplant) Vol. 15 Issue 12 Pg. 3255-8 (Dec 2015) ISSN: 1600-6143 [Electronic] United States
• PMID: 26372924 (Publication Type: Case Reports, Journal Article)
• Copyright: © Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.

Topics

• Adult
• Glomerular Filtration Rate
• Graft Survival
• Humans
• Immune Reconstitution Inflammatory Syndrome (diagnosis, etiology)
• Kidney Failure, Chronic (microbiology, surgery)
• Kidney Function Tests
• Kidney Transplantation (adverse effects)
• Male
• Mycobacterium Infections, Nontuberculous (complications, microbiology)
• Mycobacterium kansasii (pathogenicity)
• Postoperative Complications
• Prognosis
• Risk Factors
• Transplant Recipients