Photodynamic Therapy using Talaporfin Sodium for the Recurrence of Cholangiocarcinoma after Surgical Resection.

Abstract

We herein report the case of a 72-year-old man who underwent photodynamic therapy (PDT) with talaporfin sodium for recurrent cholangiocarcinoma after surgical resection. Endoscopic retrograde cholangiography (ERC) showed severe stenosis with an irregular surface measuring approximately 1 cm in length from the anastomotic site, and a recurrent nodular lesion was observed at the anastomotic site of the right anterior intrahepatic bile duct on gastrointestinal endoscopy. ERC after PDT revealed a dramatic improvement in the bile duct stenosis, and the nodular lesion had disappeared. No adverse events from the PDT were detected. PDT using talaporfin sodium may be a safe alternative treatment for cholangiocarcinoma.

• Authors: Shuya Shimizu, Takahiro Nakazawa, Kazuki Hayashi, Itaru Naitoh, Katsuyuki Miyabe, Hiromu Kondo, Yuji Nishi, Shuichiro Umemura, Yasuki Hori, Akihisa Kato, Tomohito Morisaki, Atsushi Nanashima, Hirotaka Ohara, Takashi Joh
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 54 Issue 18 Pg. 2321-6 ( 2015) ISSN: 1349-7235 [Electronic] Japan
• PMID: 26370855 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Photosensitizing Agents
• Porphyrins
• Talaporfin

Topics

• Aged
• Antineoplastic Agents (administration & dosage)
• Bile Duct Neoplasms (drug therapy, pathology, surgery)
• Bile Ducts, Intrahepatic
• Cholangiocarcinoma (drug therapy, pathology, surgery)
• Humans
• Male
• Neoplasm Recurrence, Local (drug therapy)
• Neoplasm, Residual (drug therapy)
• Photochemotherapy (methods)
• Photosensitizing Agents (administration & dosage)
• Porphyrins (administration & dosage)
• Treatment Outcome