Assessment of Antiviral Properties of Peramivir against H7N9 Avian Influenza Virus in an Experimental Mouse Model.

Abstract

The H7N9 influenza virus causes a severe form of disease in humans. Neuraminidase inhibitors, including oral oseltamivir and injectable peramivir, are the first choices of antiviral treatment for such cases; however, the clinical efficacy of these drugs is questionable. Animal experimental models are essential for understanding the viral replication kinetics under the selective pressure of antiviral agents. This study demonstrates the antiviral activity of peramivir in a mouse model of H7N9 avian influenza virus infection. The data show that repeated administration of peramivir at 30 mg/kg of body weight successfully eradicated the virus from the respiratory tract and extrapulmonary tissues during the acute response, prevented clinical signs of the disease, including neuropathy, and eventually protected mice against lethal H7N9 influenza virus infection. Early treatment with peramivir was found to be associated with better disease outcomes.

• Authors: Amber Farooqui, Linxi Huang, Suwu Wu, Yingmu Cai, Min Su, Pengzhou Lin, Weihong Chen, Xibin Fang, Li Zhang, Yisu Liu, Tiansheng Zeng, Stephane G Paquette, Adnan Khan, Alyson A Kelvin, David J Kelvin
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 59 Issue 12 Pg. 7255-64 (Dec 2015) ISSN: 1098-6596 [Electronic] United States
• PMID: 26369969 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Farooqui et al.

Chemical References

• Acids, Carbocyclic
• Antiviral Agents
• Cyclopentanes
• Enzyme Inhibitors
• Guanidines
• Viral Proteins
• Oseltamivir
• Neuraminidase
• peramivir

Topics

• Acids, Carbocyclic
• Animals
• Antiviral Agents (pharmacology)
• Cyclopentanes (pharmacology)
• Dogs
• Drug Administration Schedule
• Enzyme Inhibitors (pharmacology)
• Female
• Guanidines (pharmacology)
• Humans
• Influenza A Virus, H7N9 Subtype (drug effects, enzymology, growth & development)
• Injections, Intramuscular
• Lung (drug effects, pathology, virology)
• Madin Darby Canine Kidney Cells
• Mice
• Mice, Inbred C57BL
• Neuraminidase (antagonists & inhibitors, metabolism)
• Orthomyxoviridae Infections (drug therapy, mortality, pathology, virology)
• Oseltamivir (pharmacology)
• Survival Analysis
• Treatment Outcome
• Viral Load (drug effects)
• Viral Proteins (antagonists & inhibitors, metabolism)
• Virus Replication (drug effects)