Anthracene-9-carboxylic acid and haematological and biochemical variables in the rat.

Abstract

Chronic administration of anthracene-9-carboxylic acid in Long-Evans rats had no significant effect on the following haematological and biochemical variables: haemoglobin, haematocrit, serum sodium, potassium, glucose, cholesterol and proteins. In agreement with previous reports, significant age-related differences of glucose and cholesterol concentration were observed. A decrease of body weight was the main finding. The similarities between the myotonia induced by anthracene-9-carboxylic acid and the characteristic myotonic, haematological and biochemical alterations in patients with myotonia congenita, suggest that, despite untoward effects such as a decrease of body weight, chronic anthracene-9-carboxylic acid administration appears to be a good model for the study of mytonia congenita.

• Authors: A Villegas-Navarro, Z Jiménez-Salas, J L Reyes
• Journal: Archives internationales de pharmacodynamie et de therapie (Arch Int Pharmacodyn Ther) 1989 Nov-Dec Vol. 302 Pg. 290-8 ISSN: 0003-9780 [Print] Belgium
• PMID: 2636824 (Publication Type: Journal Article)

Chemical References

• Anthracenes
• Blood Glucose
• 9-anthroic acid
• Cholesterol

Topics

• Aging (physiology)
• Animals
• Anthracenes (pharmacology)
• Blood Glucose (metabolism)
• Body Weight (drug effects)
• Cholesterol (blood)
• Female
• Male
• Myotonia (chemically induced, physiopathology)
• Rats
• Sex Factors