HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Yohimbine is a 5-HT1A agonist in rats in doses exceeding 1 mg/kg.

Abstract
Yohimbine is a prototypical alpha2-adrenergic receptor antagonist. Due to its relatively high selectivity, yohimbine is often used in experiments whose purpose is to examine the role of these receptors. For example, yohimbine has been employed at doses of 1-5 mg/kg to reinstate drug-seeking behavior after extinction or to antagonize general anesthesia, an effects presumably being a consequence of blocking alpha2-adrenergic receptors. In this report we characterized dose-dependent autonomic and behavioral effects of yohimbine and its interaction with an antagonist of 5-HT1A receptors, WAY 100,635. In low doses (0.5-2 mg/kg i.p.) yohimbine induced locomotor activation which was accompanied by a tachycardia and mild hypertension. Increasing the dose to 3-4.5 mg/kg reversed the hypertension and locomotor activation and induced profound hypothermia. The hypothermia as well as the suppression of the locomotion and the hypertension could be reversed by the blockade of 5-HT1A receptors with WAY 100635. Our data confirm that yohimbine possesses 5-HT1A properties, and demonstrated that in doses above 1mg/kg significantly activate these receptors.
AuthorsDmitry V Zaretsky, Maria V Zaretskaia, Joseph A DiMicco, Daniel E Rusyniak
JournalNeuroscience letters (Neurosci Lett) Vol. 606 Pg. 215-9 (Oct 08 2015) ISSN: 1872-7972 [Electronic] Ireland
PMID26366943 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
CopyrightCopyright © 2015 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Piperazines
  • Pyridines
  • Serotonin 5-HT1 Receptor Agonists
  • Serotonin 5-HT1 Receptor Antagonists
  • Yohimbine
  • N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
Topics
  • Animals
  • Blood Pressure (drug effects)
  • Body Temperature (drug effects)
  • Dose-Response Relationship, Drug
  • Heart Rate (drug effects)
  • Male
  • Motor Activity (drug effects)
  • Piperazines (pharmacology)
  • Pyridines (pharmacology)
  • Rats, Sprague-Dawley
  • Serotonin 5-HT1 Receptor Agonists (administration & dosage, pharmacology)
  • Serotonin 5-HT1 Receptor Antagonists (pharmacology)
  • Yohimbine (administration & dosage, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: