HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Participation of WNT and β-Catenin in Physiological and Pathological Endometrial Changes: Association with Angiogenesis.

Abstract
WNT proteins are involved in embryonic development, sex determination, stem cell recruitment, angiogenesis, and cancer. They take part in morphological changes in the endometrium during development, regulate processes of endometrial proliferation and differentiation. This review presents current knowledge about implication of WNT proteins and β-catenin in physiological endometrial functions as well as their involvement in uterine carcinogenesis. Influence of WNT proteins on the formation of blood vessel, taking place both under healthy and pathological conditions, is also considered. Participation of WNT proteins, β-catenin, and inhibitors and inducers of WNT signaling in the process of endometrial angiogenesis is largely unknown. Thus, confirmation of their local and systemic participation in the process of endometrial angiogenesis may in the long term help to establish new diagnostic and therapeutic approaches in conditions associated with the pathology of the female reproductive system.
AuthorsJolanta Kiewisz, Tomasz Wasniewski, Zbigniew Kmiec
JournalBioMed research international (Biomed Res Int) Vol. 2015 Pg. 854056 ( 2015) ISSN: 2314-6141 [Electronic] United States
PMID26366420 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Wnt Proteins
  • beta Catenin
Topics
  • Cell Differentiation (physiology)
  • Endometrium (metabolism, pathology)
  • Female
  • Humans
  • Neovascularization, Pathologic (metabolism, pathology)
  • Wnt Proteins (metabolism)
  • beta Catenin (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: