Abstract | BACKGROUND: METHODS: A study of 91 IHH, 27 CDP patients, 6 prepubertal children, and 20 pubertal adults was undertaken. Blood samples were obtained at 0, 30, 60, and 120 min after GnRH administration and the levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were measured. For each parameter, the sensitivities and specificities were estimated, and the receiver operating characteristic (ROC) curves were constructed. RESULTS: The ROC curves indicated that a serum basal LH <0.6 IU/L or peak LH <9.74 IU/L resulted in moderate sensitivity (73.8% or 80.0%) and specificity (90.9% or 86.4%) in the diagnosis of HH in males. Serum basal LH <0.85 IU/L or basal FSH <2.43 IU/L resulted in moderate sensitivity (80.0% or 100.0%) and specificity (75.0% or 50.0%) in the diagnosis of HH in females. CONCLUSIONS: Our data suggest that isolated use of the gonadorelin stimulation test is almost sufficient to discriminate between HH and CDP in males, but unnecessary in females. The most useful predictor is serum basal or peak LH to differentiate these two disorders in males, but serum basal LH or FSH in females.
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Authors | Qi-Hong Sun, Yu Zheng, Xiao-Lin Zhang, Yi-Ming Mu |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 128
Issue 18
Pg. 2439-43
(Sep 20 2015)
ISSN: 2542-5641 [Electronic] China |
PMID | 26365959
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Gonadotropins
- Gonadotropin-Releasing Hormone
- Luteinizing Hormone
- Follicle Stimulating Hormone
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Topics |
- Adolescent
- Female
- Follicle Stimulating Hormone
(blood)
- Gonadotropin-Releasing Hormone
(pharmacology)
- Gonadotropins
(deficiency)
- Humans
- Hypogonadism
(blood, diagnosis)
- Hypothalamus
(drug effects)
- Luteinizing Hormone
(blood)
- Male
- Pituitary Gland
(drug effects)
- Puberty, Delayed
(blood, diagnosis)
- Sensitivity and Specificity
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