Electrochemical detection of type 2 diabetes mellitus-related SNP via DNA-mediated growth of silver nanoparticles on single walled carbon nanotubes.

Abstract

Herein, we proposed a new electrochemical sensing strategy for T2DM-related SNP detection via DNA-mediated growth of AgNPs on a SWCNT-modified electrode. Coupled with RNase HII enzyme assisted amplification, this approach could realize T2DM-related SNP assay and be applied in crude extracts of carcinoma pancreatic β-cell lines.

• Authors: Jia Tao, Peng Zhao, Jing Zheng, Cuichen Wu, Muling Shi, Jishan Li, Yinhui Li, Ronghua Yang
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 51 Issue 86 Pg. 15704-7 (Nov 07 2015) ISSN: 1364-548X [Electronic] England
• PMID: 26365891 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Nanotubes, Carbon
• Silver
• DNA
• ribonuclease HII
• Ribonuclease H

Topics

• Cell Line, Tumor
• DNA (chemistry)
• Diabetes Mellitus, Type 2 (genetics)
• Electrochemical Techniques
• Electrodes
• Humans
• Metal Nanoparticles (chemistry)
• Nanotubes, Carbon (chemistry)
• Polymorphism, Single Nucleotide
• Ribonuclease H (chemistry)
• Silver (chemistry)