HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

A short-type peptidoglycan recognition protein from tongue sole (Cynoglossus semilaevis) promotes phagocytosis and defense against bacterial infection.

Abstract
Peptidoglycan recognition proteins (PGRPs) are members of the innate immune system that interact with bacteria by binding to bacterial peptidoglycan. In this study, we examined the expression and function of a short type of PGRP, CsPGRP-SC2, from tongue sole (Cynoglossus semilaevis). CsPGRP-SC2 contains 164 amino acid residues and shares 54.5%-65.3% overall sequence identities with other teleost PGRPs. CsPGRP-SC2 possesses an amidase domain with a conserved zinc binding site. CsPGRP-SC2 expression occurred in multiple tissues and was upregulated by bacterial and viral infection. Purified recombinant CsPGRP-SC2 (rCsPGRP-SC2) was able to bind and agglutinate Gram-positive bacteria in a Zn(2+)-dependent manner. rCsPGRP-SC2 enhanced the uptake of the bound bacteria by host phagocytes and reduced bacterial dissemination and colonization in host tissues. These results indicate that CsPGRP-SC2 is an innate immune factor that participates in host defense against bacterial infection.
AuthorsQing-lei Sun, Li Sun
JournalFish & shellfish immunology (Fish Shellfish Immunol) Vol. 47 Issue 1 Pg. 313-20 (Nov 2015) ISSN: 1095-9947 [Electronic] England
PMID26364742 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier Ltd. All rights reserved.
Chemical References
  • Carrier Proteins
  • Fish Proteins
  • peptidoglycan recognition protein
Topics
  • Amino Acid Sequence
  • Animals
  • Carrier Proteins (chemistry, genetics, metabolism)
  • DNA Virus Infections (genetics, immunology, veterinary, virology)
  • Fish Diseases (genetics, immunology, microbiology, virology)
  • Fish Proteins (chemistry, genetics, metabolism)
  • Flatfishes
  • Immunity, Innate
  • Iridoviridae (physiology)
  • Phagocytosis
  • Real-Time Polymerase Chain Reaction (veterinary)
  • Sequence Alignment (veterinary)
  • Streptococcal Infections (genetics, immunology, microbiology, veterinary)
  • Streptococcus (physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: