Meta-analysis of vitamin D-binding protein and cancer risk.

Abstract

BACKGROUND:

Epidemiologic evidence supported a role for vitamin D and vitamin D receptor (VDR) polymorphisms in cancer risk. Beyond VDR, the biologic effects of vitamin D are mediated by the vitamin D-binding protein (DBP), a key protein in vitamin D metabolism. Furthermore, the gene encoding the DBP (GC, group-specific component) has an important role in the vitamin D pathway. Several studies investigated DBP serologic levels and GC polymorphisms in association with cancer risk with controversial results. Thus, we carried out a meta-analysis to investigate these associations.

METHODS:

We included 28 independent studies concerning the following tumors: basal cell carcinoma, bladder, breast, colon-rectum, endometrium, liver, esophagus, stomach, melanoma, pancreas, prostate, and kidney. Through random-effect models, we calculated the summary odds ratios (SOR) for serum DBP and the GC polymorphisms rs2282679, rs12512631, rs7041, rs4588, rs17467825, rs1155563, and rs1352844.

RESULTS:

We found a borderline decrease in cancer risk for subjects with high compared with low levels of DBP [SOR, 0.75; 95% confidence interval (CI), 0.56-1.00]. Dose-response meta-analysis indicates a nonsignificant decrease risk for an increase of 1,000 nmol/L of DBP (SOR, 0.96; 95% CI, 0.91-1.01). We found no significant alterations in cancer risk for subjects carrying any of the studied GC polymorphisms compared with wild-type subjects both in the main analysis and in analyses stratified by cancer type and ethnicity.

CONCLUSIONS:

We found trends toward significance, suggesting a role of DBP in cancer etiology, which should be confirmed in further studies.

IMPACT:

To our knowledge, this is the first study to investigate GC polymorphisms and DBP serologic levels in association with any type of cancer.

• Authors: Elena Tagliabue, Sara Raimondi, Sara Gandini
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 24 Issue 11 Pg. 1758-65 (Nov 2015) ISSN: 1538-7755 [Electronic] United States
• PMID: 26364161 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
• Copyright: ©2015 American Association for Cancer Research.

Chemical References

• Vitamin D-Binding Protein

Topics

• Genetic Predisposition to Disease (genetics)
• Humans
• Neoplasms (blood, genetics)
• Polymorphism, Single Nucleotide (genetics)
• Risk Factors
• Vitamin D-Binding Protein (blood, genetics)