Abstract | INTRODUCTION: MATERIALS AND METHODS: We retrospectively analyzed 10 consecutive patients with cryptococcal meningitis who were refractory to systemic administration of antifungal drugs. RESULTS:
Fever or nausea occurred in most patients. However, no patient complained of serious complications such as renal toxicity. Seven patients recovered completely or partially, whereas three patients died. CONCLUSIONS: To establish the efficacy of the intraventricular infusion of antifungal drugs through Ommaya reservoirs for cryptococcal meningitis, a prospective investigation should be designed to compare those treated according to the updated guidelines and those treated with antifungal drugs through the Ommaya reservoirs.
|
Authors | Tatsuya Nakama, Satoshi Yamashita, Tomoo Hirahara, Sadahisa Okamoto, Shoji Honda, Masaki Watanabe, En Kimura, Makoto Uchino, Shigetoshi Yano, Jun-ichi Kuratsu, Yukio Ando |
Journal | Journal of the neurological sciences
(J Neurol Sci)
Vol. 358
Issue 1-2
Pg. 259-62
(Nov 15 2015)
ISSN: 1878-5883 [Electronic] Netherlands |
PMID | 26362338
(Publication Type: Journal Article)
|
Copyright | Copyright © 2015 Elsevier B.V. All rights reserved. |
Chemical References |
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Antifungal Agents
(administration & dosage, therapeutic use)
- Drug Delivery Systems
- Female
- Humans
- Male
- Meningitis, Cryptococcal
(drug therapy)
- Middle Aged
- Retrospective Studies
- Treatment Outcome
|