[The effect of depletion depletion macrophages on tumor-suppressive activity of polyactin A].

Abstract

Trypan blue(T. blue) was used to block macrophages (M phi) for investigating the role of M phi in tumor-suppressing activity of polyactin A, a mannose-peptide immunomodulator extracted from alpha-streptococcus. Results showed that polyactin A could significantly inhibit the growth of transplanted S 180 tumor in mice. Anyhow, when M phi activities were blocked by T. blue, the protective effect of polyactin A was almost completely lost. Moreover, T. blue-treated mice showed larger tumor size than the controls. In addition, marked hemorrhagic necrosis was seen in the polyactin A-treated tumor, and the area of necrosis was larger than that in the controls. No significant difference was seen between T. blue-treated group and the controls. Furthermore, more M type ANAE+ cells were seen in the peripheral area of the tumors in polyactin A-treated groups than in any other group. All these findings suggest that the in vivo antitumor effect of polyactin A is produced mainly through M phi mechanisms.

• Authors: G P Chen
• Journal: Zhonghua bing li xue za zhi = Chinese journal of pathology (Zhonghua Bing Li Xue Za Zhi) Vol. 18 Issue 3 Pg. 217-20 (Sep 1989) ISSN: 0529-5807 [Print] China
• PMID: 2636067 (Publication Type: English Abstract, Journal Article)

Chemical References

• Glycopeptides
• Immunologic Factors
• polyactin A
• Trypan Blue

Topics

• Animals
• Female
• Glycopeptides (pharmacology)
• Immunologic Factors (pharmacology)
• Macrophage Activation
• Macrophages (physiology)
• Male
• Mice
• Mice, Inbred C57BL
• Sarcoma 180 (pathology)
• Trypan Blue (pharmacology)