Modifiable Lifestyle Factors and Triple-negative Breast Cancer Survival: A Population-based Prospective Study.

Abstract

BACKGROUND:

Very little is known about the effect of modifiable lifestyle factors on outcomes of triple-negative breast cancer. We examined this association in a population-based prospective cohort study of patients with triple-negative breast cancer.

METHODS:

A total of 518 women with confirmed triple-negative breast cancer, recruited by the Shanghai Breast Cancer Survival Study, completed 6-, 18-, 36-, and 60-month postdiagnosis surveys. We applied Cox proportional hazard models to evaluate the associations.

RESULTS:

The mean age at diagnosis was 53.4 (standard deviation = 10.6) years old. After a median follow-up of 9.1 years (range: 0.6-11.8), 128 deaths and 112 recurrences were documented. Exercise during the first 60 months postdiagnosis was inversely associated with total mortality and recurrence/disease-specific mortality with adjusted hazard ratios (HRs) of 0.67 (95% confidence interval [CI] = 0.46, 0.96) and 0.58 (95% CI = 0.39, 0.86), respectively. Women with higher exercise-metabolic equivalent scores (≥7.6 metabolic equivalent-hours/week) and longer duration of exercise (≥2.5 hours/week) had lower risk of total and recurrence/disease-specific mortality than did nonexercisers. Compared with nontea drinkers, survival was better among women who were regular tea drinkers during the first 60 months for all cause (HR = 0.57, 95% CI = 0.34, 0.93) and recurrence/disease-specific mortality (HR = 0.54, 95% CI = 0.31, 0.96). There was no dose-response pattern for tea consumption. No interactions were observed for body mass index, menopausal status, and comorbidity.

CONCLUSIONS:

These findings show that postdiagnosis exercise and tea intake were associated with improved survival among women with triple-negative breast cancer.

• Authors: Ping-Ping Bao, Gen-Ming Zhao, Xiao-Ou Shu, Peng Peng, Hui Cai, Wei Lu, Ying Zheng
• Journal: Epidemiology (Cambridge, Mass.) (Epidemiology) Vol. 26 Issue 6 Pg. 909-16 (Nov 2015) ISSN: 1531-5487 [Electronic] United States
• PMID: 26360370 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Tea

Topics

• Adult
• Aged
• Body Mass Index
• China (epidemiology)
• Comorbidity
• Diet (statistics & numerical data)
• Disease-Free Survival
• Exercise
• Female
• Humans
• Metabolic Equivalent
• Middle Aged
• Obesity (epidemiology)
• Proportional Hazards Models
• Prospective Studies
• Survival Rate
• Tea
• Time Factors
• Triple Negative Breast Neoplasms (mortality)