Abstract |
The evaluation of the tumorigenic activity in A/J mouse lung of certain tobacco N- nitrosamines, namely 3-(methylnitrosamino)propionic acid ( NMPA), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-4-(3-pyridyl)-butyric acid ( iso-NNAC), had the following results (total dose in micromol per mouse/lung tumors per mouse): NMPA (200/7.1 +/- 2.9); NNK (2/15.7 +/- 4.1); iso-NNAC (200/0.24 +/- 0.43); saline control (0.2 +/- 0.4). The tumorigenic activity of NMPA was not surprising since its lower homologue, N-nitrososarcosine, as well as its higher homologue, 4-(methylnitrosamino)-butyric acid, are known carcinogens. The high tumorigenic activity of NNK in strain A/J mice confirms earlier findings as to its carcinogenic potency in rats and hamsters. The lack of tumorigenic activity of iso-NNAC supports the observation that the pyridyl rest adjacent to the nitrosamino group inhibits the activity of some tobacco-specific N- nitrosamines (TSNA). Iso-NNAC is most likely formed endogenously from the nicotine metabolites cotinine and 4-(methylamino)-4-(3-pyridyl)butyric acid.
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Authors | A Rivenson, M V Djordjevic, S Amin, R Hoffmann |
Journal | Cancer letters
(Cancer Lett)
Vol. 47
Issue 1-2
Pg. 111-4
(Sep 15 1989)
ISSN: 0304-3835 [Print] Ireland |
PMID | 2636026
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Carcinogens
- Nitrosamines
- 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
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Topics |
- Animals
- Carcinogens
- Female
- Mice
- Neoplasms, Experimental
(chemically induced)
- Nitrosamines
(toxicity)
- Plants, Toxic
- Tobacco
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