Dynamic Contrast-Enhanced MRI Using a Macromolecular MR Contrast Agent (P792): Evaluation of Antivascular Drug Effect in a Rabbit VX2 Liver Tumor Model.

Abstract

OBJECTIVE:

To evaluate the utility of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using macromolecular contrast agent (P792) for assessment of vascular disrupting drug effect in rabbit VX2 liver tumor models.

MATERIALS AND METHODS:

This study was approved by our Institutional Animal Care and Use Committee. DCE-MRI was performed with 3-T scanner in 13 VX2 liver tumor-bearing rabbits, before, 4 hours after, and 24 hours after administration of vascular disrupting agent (VDA), using gadomelitol (P792, n = 7) or low molecular weight contrast agent (gadoterate meglumine [Gd-DOTA], n = 6). P792 was injected at a of dose 0.05 mmol/kg, while that of Gd-DOTA was 0.2 mmol/kg. DCE-MRI parameters including volume transfer coefficient (K(trans)) and initial area under the gadolinium concentration-time curve until 60 seconds (iAUC) of tumors were compared between the 2 groups at each time point. DCE-MRI parameters were correlated with tumor histopathology. Reproducibility in measurement of DCE-MRI parameters and image quality of source MR were compared between groups.

RESULTS:

P792 group showed a more prominent decrease in K(trans) and iAUC at 4 hours and 24 hours, as compared to the Gd-DOTA group. Changes in DCE-MRI parameters showed a weak correlation with histologic parameters (necrotic fraction and microvessel density) in both groups. Reproducibility of DCE-MRI parameters and overall image quality was not significantly better in the P792 group, as compared to the Gd-DOTA group.

CONCLUSION:

Dynamic contrast-enhanced magnetic resonance imaging using a macromolecular contrast agent shows changes of hepatic perfusion more clearly after administration of the VDA. Gadolinium was required at smaller doses than a low molecular contrast agent.

• Authors: Hee Sun Park, Joon Koo Han, Jeong Min Lee, Young Il Kim, Sungmin Woo, Jung Hwan Yoon, Jin-Young Choi, Byung Ihn Choi
• Journal: Korean journal of radiology (Korean J Radiol) 2015 Sep-Oct Vol. 16 Issue 5 Pg. 1029-37 ISSN: 2005-8330 [Electronic] Korea (South)
• PMID: 26357497 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Benzophenones
• Heterocyclic Compounds
• N-(4-(3-(1H-1,2,4-triazol-1-yl)-4-(3,4,5-trimethoxybenzoyl)phenyl)thiazol-2-yl)-2-amino-3-methylbutanamide
• Organometallic Compounds
• gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate
• Valine
• contrast agent P792

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Benzophenones (therapeutic use)
• Disease Models, Animal
• Heterocyclic Compounds (administration & dosage, chemistry)
• Liver Neoplasms (diagnostic imaging, drug therapy, pathology)
• Magnetic Resonance Imaging
• Male
• Organometallic Compounds (administration & dosage, chemistry)
• Rabbits
• Radiography
• Reproducibility of Results
• Valine (analogs & derivatives, therapeutic use)