Tetramic Acids and Pyridone Alkaloids from the Endolichenic Fungus Tolypocladium cylindrosporum.

Abstract

Three new tetramic acid derivatives, tolypocladenols A1, A2, and B (1-3), a new pyridone alkaloid, tolypyridone A (4), and a new coumarin derivative, 3,8-dihydroxy-4-(4-hydroxyphenyl)-6-methylcoumarin (5), together with four known compounds (6-9) were isolated from the endolichenic fungus Tolypocladium cylindrosporum, which inhabits the lichen Lethariella zahlbruckneri. Structures of these compounds were determined by comprehensive analysis of spectroscopic data and single-crystal X-ray diffraction determination. Bioassay of the isolated compounds found that pyridoxatin (7) was cytotoxic to human cancer cells by induction of G0/G1 cell cycle arrest and apoptosis.

• Authors: Xiao-Bin Li, Lin Li, Rong-Xiu Zhu, Wei Li, Wen-Qiang Chang, Lu-Lu Zhang, Xiao-Ning Wang, Zun-Tian Zhao, Hong-Xiang Lou
• Journal: Journal of natural products (J Nat Prod) Vol. 78 Issue 9 Pg. 2155-60 (Sep 25 2015) ISSN: 1520-6025 [Electronic] United States
• PMID: 26356746 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkaloids
• Antineoplastic Agents
• Pyridones
• Pyrrolidinones
• tolypyridone A
• tetramic acid

Topics

• Alkaloids (chemistry, isolation & purification, pharmacology)
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Cell Cycle (drug effects)
• Drug Screening Assays, Antitumor
• Humans
• Molecular Structure
• Pyridones (chemical synthesis, chemistry, isolation & purification, pharmacology)
• Pyrrolidinones (chemistry, isolation & purification, pharmacology)