Abstract | BACKGROUND: CASE PRESENTATION: An adult male with metastatic medullary thyroid cancer presented with hyperglycemia, hypernatremia, hypokalemia, hypertension, acne-like rash, and diabetes insipidus (urine volume >8 L/d, osmolality 190 mOsm/kg). Serum cortisol, adrenocorticoitropic hormone, dehydroepiandrostenedione sulfate, and urinary free cortisol were elevated 8, 20, 4.4, and 340 folds, respectively. Pituitary imaging was normal. Computed tomography scan revealed jejunal intussusception and incidental abdominal aortic dissection. Sorafenib treatment was associated with Cushing's syndrome remission, elevated progesterone (>10 fold), normalization of dehydroepiandrostenedione sulfate, but persistently elevated cortisol concentration. Newly-developed proximal lower limb weakness and decreased salivation were associated with elevated ganglionic neuronal acetylcholine receptor (alpha-3) and borderline P/ Q type calcium channel antibodies. CONCLUSION:
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Authors | Muhammad M Hammami, Najla Duaiji, Ghazi Mutairi, Sabah Aklabi, Nasser Qattan, Mohei El-Din M Abouzied, Mohamed W Sous |
Journal | BMC cancer
(BMC Cancer)
Vol. 15
Pg. 624
(Sep 09 2015)
ISSN: 1471-2407 [Electronic] England |
PMID | 26354794
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Phenylurea Compounds
- Niacinamide
- Sorafenib
- Hydrocortisone
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Topics |
- Adult
- Aortic Dissection
(etiology)
- Antineoplastic Agents
(therapeutic use)
- Aortic Aneurysm
(etiology)
- Carcinoma, Medullary
(complications, drug therapy)
- Cushing Syndrome
(drug therapy, etiology)
- Diabetes Insipidus
(etiology)
- Fatal Outcome
- Humans
- Hydrocortisone
(blood)
- Intussusception
(etiology)
- Jejunal Diseases
(etiology)
- Male
- Niacinamide
(analogs & derivatives, therapeutic use)
- Paraneoplastic Polyneuropathy
(etiology)
- Phenylurea Compounds
(therapeutic use)
- Primary Dysautonomias
(etiology)
- Sorafenib
- Thyroid Neoplasms
(complications, drug therapy)
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