CRYSTALLOID PRELOAD SHOWS TRANSIENT SUPERIORITY OVER COLLOID, OR THEIR COMBINATION IN SPINAL ANAESTHESIA-INDUCED HYPOTENSION PROPHYLAXIS FOR CAESAREAN SECTION.

Abstract

BACKGROUND:

Many studies comparing different intravenous fluid types usually do not use equipotent volumes of 3:1 crystalloid: colloid ratio in such comparisons. Conflicting results emanate from such studies. This study was designed to compare the efficacy of equipotent volumes of crystalloid, colloid and combination of crystalloid/colloid in spinal anaesthesia-induced hypotension prophylaxis.

METHODOLOGY:

Pregnant women scheduled for elective Caesarean section were prospectively randomized to three groups to each received either 1 500 ml of Ringers lactate, or 500 ml of 6% pentastarch or a combination of 250 ml of 6% pentastarch and 750 ml of Ringers lactate intravenous fluid preload, before spinal anaesthesia. Hemodynamic variables were monitored.

RESULTS:

First 10 minutes, crystalloid showed better efficacy in hypotension prophylaxis over the other regimen. In the next 30 minutes however, there were no significant differences between the groups.

CONCLUSION:

Crystalloids proved more effective than colloid or their combination in hypotension prophylaxis in the first 10 minutes after spinal anaesthesia.

• Authors: Idehen Hanson Osazuwa, Amadasun Ebague
• Journal: Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria (Niger J Med) 2015 Apr-Jun Vol. 24 Issue 2 Pg. 137-43 ISSN: 1115-2613 [Print] Nigeria
• PMID: 26353424 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Colloids
• Crystalloid Solutions
• Isotonic Solutions
• Rehydration Solutions

Topics

• Adult
• Anesthesia, Obstetrical (adverse effects, methods)
• Anesthesia, Spinal (adverse effects, methods)
• Cesarean Section (methods)
• Colloids (administration & dosage, adverse effects)
• Crystalloid Solutions
• Dose-Response Relationship, Drug
• Double-Blind Method
• Drug Monitoring
• Drug Therapy, Combination
• Female
• Fluid Therapy (methods)
• Humans
• Hypotension (etiology, prevention & control)
• Isotonic Solutions (administration & dosage, adverse effects)
• Pregnancy
• Rehydration Solutions (administration & dosage, adverse effects)
• Treatment Outcome