Stromal Overgrowth in a Brenner Tumor or Ovarian Fibroma With Minor Sex Cord Elements?

Abstract

Computed tomography obtained as part of a urinary tract assessment in a 68-year-old woman incidentally detected a solid adnexal mass. Bilateral salpingo-oophorectomy revealed a unilateral, 4-cm, white to tan-yellow colored, focally calcified, left ovarian mass. Microscopically, the tumor was composed of bland fibroblasts, abundant collagen, and areas of calcification with a minor component composed of nests of epithelial cells with nuclear clefts focally evident, some of which contained central lumens with eosinophilic secretions. The major considerations were fibromatous overgrowth in a Brenner tumor or ovarian fibroma with minor sex cord elements. Immunostains for cytokeratin 7 showed diffuse positivity in the epithelial nests, whereas cytokeratin 20 and inhibin were negative, further supporting the diagnosis of a Brenner tumor.

• Authors: Julia A Ross, Ozlen Saglam
• Journal: Cancer control : journal of the Moffitt Cancer Center (Cancer Control) Vol. 22 Issue 3 Pg. 366-8 (Jul 2015) ISSN: 1526-2359 [Electronic] United States
• PMID: 26351894 (Publication Type: Case Reports, Journal Article)

Topics

• Aged
• Brenner Tumor (metabolism, pathology)
• Female
• Fibroma (metabolism, pathology)
• Humans
• Ovarian Neoplasms (metabolism, pathology)
• Sex Cord-Gonadal Stromal Tumors (metabolism, pathology)