Lamotrigine-induced tubulointerstitial nephritis and uveitis-atypical Cogan syndrome.

Abstract

PURPOSE:

To report a case of lamotrigine-induced tubulointerstitial nephritis and uveitis (TINU)-atypical Cogan syndrome.

METHODS:

Case report.

RESULTS:

A 16-year-old boy with traumatic brain injury and seizures presented to the emergency department with facial swelling, rash, and back pain several days after increasing lamotrigine dose secondary to a breakthrough seizure. Creatinine, urine β2 microglobulin, and eosinophils were elevated. Antinuclear antibodies, antineutrophil cytoplasmic antibodies, angiotensin-converting enzyme, and complement were normal. Renal biopsy showed acute granulomatous tubulointerstitial nephritis. Lamotrigine was discontinued, intravenous steroids were initiated, and the patient was discharged on Ativan and prednisone. Subsequently, he was diagnosed with bilateral anterior uveitis (vision 20/30 bilaterally) and started on prednisolone and cyclopentolate. Two months later, he developed a branch retinal artery occlusion in the right eye (vision 20/70) and bilateral ocular hypertension for which timolol-brimonidine and dorzolamide were added. Neuroimaging and hypercoagulability workup was unremarkable. Vision and intraocular pressure improved, while uveitis remained recalcitrant. Several months later, the patient developed central serous retinopathy in the right eye (vision 20/30). Prednisone was stopped but restarted due to methotrexate intolerance. A month later, he reported dizziness and was diagnosed with severe bilateral sensorineural hearing loss. Brain magnetic resonance imaging showed foci of perivascular, subcortical, and cochlear enhancement. Transtympanic Decadron injections and infliximab infusions were initiated. At the final visit, vision remained at 20/30 with trace anterior chamber reaction bilaterally while on timolol-brimonidine, dorzolamide, and prednisolone.

CONCLUSIONS:

An idiosyncratic drug reaction should be considered in the differential diagnosis of TINU-atypical Cogan syndrome.

• Authors: Anton M Kolomeyer, Shyam Kodati
• Journal: European journal of ophthalmology (Eur J Ophthalmol) Vol. 26 Issue 1 Pg. e14-6 (Dec 01 2015) ISSN: 1724-6016 [Electronic] United States
• PMID: 26350991 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticonvulsants
• Glucocorticoids
• Triazines
• Fluprednisolone
• Prednisolone
• difluprednate
• Lamotrigine
• Prednisone

Topics

• Adolescent
• Anticonvulsants (adverse effects)
• Cogan Syndrome (chemically induced, diagnosis, drug therapy)
• Diagnosis, Differential
• Drug Therapy, Combination
• Fluprednisolone (analogs & derivatives, therapeutic use)
• Glucocorticoids (therapeutic use)
• Humans
• Lamotrigine
• Magnetic Resonance Angiography
• Male
• Nephritis, Interstitial (chemically induced, diagnosis, drug therapy)
• Prednisolone (therapeutic use)
• Prednisone (therapeutic use)
• Tomography, Optical Coherence
• Triazines (adverse effects)
• Uveitis (chemically induced, diagnosis, drug therapy)