Abstract | BACKGROUND: New, safer, and more effective agents to treat hyperlipidemia and thereby prevent cardiovascular events are under research. OBJECTIVE: METHODS: Overall, 216 subjects (124 males and 92 females; age, 18-75 years) with moderate dyslipidemia ( triglyceride [TG], 2.3-6.5 mmol/L) were randomly divided into 2 groups administered CoA 400 U/d (n = 111) or pantethine 600 U/d (n = 105). Blood lipoproteins, liver and renal function, blood glucose, and complete blood count were measured at baseline and after 4- and 8-week treatment. RESULTS: TG reduction was 26.0% with CoA and 17.4% with pantethine after 4 weeks and 33.3% and 16.5% after 8 weeks; compared with baseline, the reduction was significant (P < .01) in both groups. The difference between the 2 groups was significant at both 4 weeks (P = .0413) and 8 weeks (P < .001). Compared with baseline, total cholesterol and non- high-density lipoprotein cholesterol (non-HDL-C) were reduced, whereas HDL-C was increased with CoA after 8 weeks (all P < .05). Compared with pantethine, total cholesterol (P = .026) and non-HDL-C (P = .005) were significantly reduced after 8 weeks of CoA treatment. There was no statistical difference in low-density lipoprotein cholesterol or HDL-C between the 2 groups (P > .05) and no difference in blood glucose, hepatic or renal function, myopathy, or gastrointestinal tract symptoms. CONCLUSIONS:
|
Authors | Ya-qin Chen, Shui-ping Zhao, Yu-hong Zhao |
Journal | Journal of clinical lipidology
(J Clin Lipidol)
2015 Sep-Oct
Vol. 9
Issue 5
Pg. 692-7
ISSN: 1933-2874 [Print] United States |
PMID | 26350816
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
|
Copyright | Copyright © 2015 National Lipid Association. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Lipoproteins
- Triglycerides
- Pantetheine
- pantethine
- Coenzyme A
|
Topics |
- Adolescent
- Adult
- Aged
- Coenzyme A
(adverse effects, pharmacology, therapeutic use)
- Double-Blind Method
- Female
- Humans
- Hyperlipidemias
(blood, drug therapy)
- Lipoproteins
(blood)
- Male
- Middle Aged
- Pantetheine
(adverse effects, analogs & derivatives, pharmacology, therapeutic use)
- Safety
- Treatment Outcome
- Triglycerides
(blood)
- Young Adult
|