[The selective toxic effect of dialdehyde derivatives of the pyrimidine nucleosides on human tumor cells].

Abstract

The impact of a number of synthetic nucleoside derivatives on the growth and survival of cultured human ovarian tumor cells (line SKOV-3) and normal human lung fibroblasts was investigated. It was shown that the dialdehyde derivatives of uridine, 1-β-D-eritrofuranozyl uracil and 3'-O-β-D-ribofuranosyl-2'-deoxythymidine, in contrast to their unoxidized counterparts, exert marked toxic effect on SKOV-3 cells. Cultured human fibroblasts were less susceptible to the damaging effect of the dialdehyde nucleosides. The dialdehyde derivative of 1-β-D-eritrofuranozyl uracil demonstrated greatest differences in the cytotoxic effect on these cultures: inhibition of tumor SKOV-3 cells growth on 50% or more was achieved at the concentrations of this compound ten times lower than in the case of normal fibroblasts.

• Authors: A S Efremova, S I Shram, M S Drenichev, G A Posypanova, N F Myasoedov, S N Mihaylov
• Journal: Biomeditsinskaia khimiia (Biomed Khim) 2015 Jul-Aug Vol. 61 Issue 4 Pg. 497-502 ISSN: 2310-6972 [Print] Russia (Federation)
• PMID: 26350741 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aldehydes
• Antineoplastic Agents
• Cytotoxins
• Furans
• Uridine

Topics

• Aldehydes (chemical synthesis, pharmacology)
• Antineoplastic Agents (chemical synthesis, pharmacology)
• Cell Line
• Cell Line, Tumor
• Cell Survival (drug effects)
• Cytotoxins (chemical synthesis, pharmacology)
• Female
• Fibroblasts (cytology, drug effects)
• Furans (chemical synthesis, pharmacology)
• Humans
• Inhibitory Concentration 50
• Organ Specificity
• Ovary (drug effects, pathology)
• Uridine (analogs & derivatives, chemical synthesis, pharmacology)