Curcumin enhances poly(ADP-ribose) polymerase inhibitor sensitivity to chemotherapy in breast cancer cells.

Abstract	Poly(ADP-ribose) polymerase (PARP) inhibitor has shown promising responses in homologous recombination (HR) repair-deficient cancer cells. More specifically, targeting HR pathway in combination with PARP inhibitor has been an effective chemotherapy strategy by so far. Curcumin has been recognized as anticancer agents for several types of cancers. Here, we demonstrate that curcumin inhibits a critical step in HR pathway, Rad51 foci formation, and accumulates γ-H2AX levels in MDA-MB-231 breast cancer cells. Curcumin also directly reduces HR and induces cell death with cotreatment of PARP inhibitor in MDA-MB-231 breast cancer cells. Moreover, curcumin, when combined with ABT-888, could effectively delayed breast tumor formation in vivo. Our study indicates that cotreatment of curcumin and PARP inhibitor might be useful for the combination chemotherapy for aggressive breast cancer treatment as a natural bioactive compound.
Authors	Young Eun Choi, Eunmi Park
Journal	The Journal of nutritional biochemistry (J Nutr Biochem) Vol. 26 Issue 12 Pg. 1442-7 (Dec 2015) ISSN: 1873-4847 [Electronic] United States
PMID	26350251 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	Copyright © 2015 Elsevier Inc. All rights reserved.
Chemical References	Antineoplastic Agents Benzimidazoles H2AX protein, human Histones Poly(ADP-ribose) Polymerase Inhibitors veliparib Green Fluorescent Proteins Poly(ADP-ribose) Polymerases RAD51 protein, human Rad51 Recombinase Curcumin
Topics	Animals Antineoplastic Agents (chemistry, pharmacology) Benzimidazoles (chemistry) Breast Neoplasms (metabolism) Cell Line, Tumor Curcumin (chemistry, pharmacology) DNA Repair (drug effects) Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Green Fluorescent Proteins (metabolism) Histones (metabolism) Humans MCF-7 Cells Mice Mice, Nude Neoplasm Transplantation Poly(ADP-ribose) Polymerase Inhibitors (chemistry) Poly(ADP-ribose) Polymerases (metabolism) Rad51 Recombinase (metabolism) Recombination, Genetic

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!