The Effects of Probiotic Soymilk Fortified with Omega-3 on Blood Glucose, Lipid Profile, Haematological and Oxidative Stress, and Inflammatory Parameters in Streptozotocin Nicotinamide-Induced Diabetic Rats.

Abstract

OBJECTIVE:

The aim of the present study was to evaluate the effects of probiotic soymilk fortified with omega-3 in diabetic rats.

METHODS:

Soymilk (SM), fermented soymilk (FSM), and fermented soymilk fortified with omega-3 (FSM + omega-3) were prepared. Rats were randomly assigned to five groups of 13 animals per group. Diabetes was induced by a single injection of streptozotocin (STZ) 15 min after the intraperitoneal administration of nicotinamide (NA). Normal control (NC) and diabetic control (DC) rats received 1 mL/day of distilled water and three groups of diabetic rats were given 1 mL/day of SM, FSM, and FSM + omega-3 products by oral gavage for 28 days.

RESULTS:

Three products significantly (P < 0.05) reduced blood glucose, total cholesterol (TC), triglyceride (TG), and malondialdehyde (MDA) concentrations compared to the DC group, with the maximum reduction seen in the FSM + omega-3 group. Body weight, red blood cells (RBC), haemoglobin (Hb), haematocrit, and superoxide dismutase (SOD) also significantly increased in the FSM + omega-3 group. In the FSM + omega-3 group, MDA level compared with the SM and FSM groups and high sensitivity C-reactive protein (hs-CRP) concentrations compared with the DC and FSM groups were significantly lower (P < 0.05).

CONCLUSION:

Fermented soymilk fortified with omega-3 may be beneficial in diabetes.

• Authors: Mohsen Mohammadi Sartang, Seyed Mohammad Mazloomi, Nader Tanideh, Abbas Rezaian Zadeh
• Journal: Journal of diabetes research (J Diabetes Res) Vol. 2015 Pg. 696372 ( 2015) ISSN: 2314-6753 [Electronic] England
• PMID: 26347893 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Fatty Acids, Omega-3
• Hemoglobins
• Lipids
• Triglycerides
• Niacinamide
• Malondialdehyde
• Streptozocin
• C-Reactive Protein
• Cholesterol
• Superoxide Dismutase

Topics

• Animals
• Blood Glucose (chemistry)
• Body Weight
• C-Reactive Protein (metabolism)
• Cholesterol (blood)
• Diabetes Mellitus, Experimental (blood, diet therapy)
• Erythrocytes (cytology)
• Fatty Acids, Omega-3 (chemistry)
• Fermentation
• Hematocrit
• Hemoglobins (analysis)
• Inflammation
• Lipids (blood)
• Male
• Malondialdehyde (blood)
• Niacinamide (chemistry)
• Oxidative Stress
• Probiotics (chemistry)
• Rats
• Rats, Sprague-Dawley
• Soy Milk
• Streptozocin (chemistry)
• Superoxide Dismutase (metabolism)
• Triglycerides (blood)