Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population.

Abstract

Alopecia areata (AA) is a common disease, which causes hair loss in humans. AA has a genetically complex inheritance. This study investigated the possible correlations between single nucleotide polymorphisms (SNPs) in the promoter regions of the chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (CXCL1) and chemokine (C-X-C motif) ligand 2 (CXCL2) genes and the development of AA in the Korean population. Two hundred and thirty-five AA patients and 240 control subjects were recruited. The specific SNPs occurring in the promoter regions of the CXCL1 and CXCL2 genes (rs3117604, -429C/T and rs3806792, -264T/C, respectively) were genotyped. All data obtained was evaluated using the SNPStats, SPSS 18.0, and the Haploview v.4.2 software platforms. The Odd's ratios (OR), 95% confidence intervals (CI), and P values were calculated using multiple logistic regression models. Analyses of the genetic sequences obtained revealed a significant correlation between the two SNPs and the development of AA (rs3117604, P = 0.0009 in co-dominant model 1, P = 0.01 in co-dominant model 2, P = 0.004 in the dominant model, P = 0.005 in the log-additive model, P = 0.012 in allele distribution; rs3806792, P = 0.036 in co-dominant model 2, P = 0.0046 in the log-additive model). The TT and CC haplotypes were also observed to show a significant association with increased risk of AA (TT haplotype, P = 0.0018; CC haplotype, P = 0.0349). Our data suggests that the CXCL1 and CXCL2 genes may be associated with AA susceptibility.

• Authors: S K Kim, J-H Chung, H J Park, S W Kang, D-J Lim, S H Byun, D G Baek, H Y Ko, B-L Lew, H H Baik, W-Y Sim
• Journal: Genetics and molecular research : GMR (Genet Mol Res) Vol. 14 Issue 3 Pg. 9667-74 (Aug 14 2015) ISSN: 1676-5680 [Electronic] Brazil
• PMID: 26345899 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chemokine CXCL1
• Chemokine CXCL2

Topics

• Adolescent
• Adult
• Alleles
• Alopecia Areata (diagnosis, epidemiology, genetics)
• Case-Control Studies
• Chemokine CXCL1 (genetics)
• Chemokine CXCL2 (genetics)
• Female
• Gene Frequency
• Genetic Association Studies
• Genetic Predisposition to Disease
• Genotype
• Haplotypes
• Humans
• Male
• Odds Ratio
• Polymorphism, Single Nucleotide
• Promoter Regions, Genetic
• Republic of Korea (epidemiology)
• Risk
• Young Adult