Kojibiose ameliorates arachidic acid-induced metabolic alterations in hyperglycaemic rats.

Abstract	Herein we hypothesise the positive effects of kojibiose (KJ), a prebiotic disaccharide, selected for reducing hepatic expression of inflammatory markers in vivo that could modulate the severity of saturated arachidic acid (ARa)-induced liver dysfunction in hyperglycaemic rats. Animals were fed daily (20 d) with ARa (0·3 mg) together or not with KJ (22 mg approximately 0·5 %, w/w diet). Glucose, total TAG and cholesterol contents and the phospholipid profile were determined in serum samples. Liver sections were collected for the expression (mRNA) of enzymes and innate biomarkers, and intrahepatic macrophage and T-cell populations were analysed by flow cytometry. ARa administration increased the proportion of liver to body weight that was associated with an increased (by 11 %) intrahepatic macrophage population. These effects were ameliorated when feeding with KJ, which also normalised the plasmatic levels of TAG and N-acyl-phosphatidylethenolamine in response to tissue damage. These results indicate that daily supplementation of KJ significantly improves the severity of ARa-induced hepatic alterations.
Authors	José Moisés Laparra, Marina Díez-Municio, F Javier Moreno, Miguel Herrero
Journal	The British journal of nutrition (Br J Nutr) Vol. 114 Issue 9 Pg. 1395-402 (Nov 14 2015) ISSN: 1475-2662 [Electronic] England
PMID	26344377 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Biomarkers Blood Glucose Disaccharides Eicosanoic Acids Phospholipids Triglycerides Cholesterol kojibiose arachidic acid
Topics	Animals Biomarkers (blood) Blood Glucose (metabolism) Body Weight Cholesterol (blood) Disaccharides (pharmacology) Disease Models, Animal Eicosanoic Acids (adverse effects) Female Hyperglycemia (chemically induced, drug therapy) Liver (drug effects, metabolism, physiopathology) Macrophages (metabolism) Organ Size (drug effects) Phospholipids (blood) Rats Rats, Wistar T-Lymphocytes (metabolism) Triglycerides (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!