Abstract | INTRODUCTION: PATIENT DESCRIPTION: A 3-year, 5-month-old girl was admitted for gradually worsening postural tremor, painful spasms, and generalized stiffness. Since the age of 3 years, she had been on adjuvant chemotherapy for pleuropulmonary blastoma before surgical resection. Brain magnetic resonance imaging and electroencephalographic findings were normal. Although serologic tests for autoimmune disease, including paraneoplastic antibodies and antiglutamic acid decarboxylase antibodies, were unremarkable, her findings were attributed to a paraneoplastic syndrome based on her clinical features and medical history. However, following the planned pulmonary lobectomy, her symptoms were paradoxically aggravated, with continuous motor unit potential at rest on electromyography, which occurs in stiff person syndrome. She gradually improved during postadjuvant chemotherapy with simultaneous immunotherapy including intravenous immunoglobulins and methylprednisolone, and she had recovered completely when evaluated at the 22-month follow-up visit after completion of her treatment for pleuropulmonary blastoma. CONCLUSION:
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Authors | Hyun-Ok Jun, Mi-Sun Yum, Eun-Hee Kim, Yun-Jeong Lee, Jong-Jin Seo, Tae-Sung Ko |
Journal | Pediatric neurology
(Pediatr Neurol)
Vol. 53
Issue 5
Pg. 448-51
(Nov 2015)
ISSN: 1873-5150 [Electronic] United States |
PMID | 26344328
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Topics |
- Child, Preschool
- Electromyography
- Female
- Follow-Up Studies
- Humans
- Lung
(diagnostic imaging, pathology)
- Paraneoplastic Syndromes, Nervous System
(etiology, pathology, physiopathology, therapy)
- Pulmonary Blastoma
(complications, pathology, physiopathology, therapy)
- Stiff-Person Syndrome
(etiology, pathology, physiopathology, therapy)
- Tomography, X-Ray Computed
- Treatment Outcome
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