Effect of nucleus accumbens shell 5-HT4 receptors on the impairment of ACPA-induced emotional memory consolidation in male Wistar rats.

Abstract

The present study investigates the effects of 5-HT4 receptors of the nucleus accumbens (NAc) shell on the impairment of emotional memory consolidation induced by cannabinoid CB1 receptor stimulation. The elevated plus maze test-retest paradigm was used to assess memory in adult male Wistar rats. Intra-NAc shell administration of ACPA (selective cannabinoid CB1 receptor agonist 0.006 µg/rat) and RS23597 (5-HT4 receptor antagonist 0.01 µg/rat), immediately after training, decreased emotional memory consolidation, suggesting a drug-induced amnesia, whereas post-training intra-NAc shell microinjections of RS67333 (5-HT4 receptor agonist 0.016 µg/rat) increased emotional memory consolidation. Interestingly, RS67333 exerted a dual effect on ACPA-induced behaviors, potentiating and restoring amnesia caused by the subthreshold and effective doses of ACPA, respectively. However, neither RS23597 nor AM251 (CB1 receptor antagonist 30, 60 and 120 ng/rat) affected emotional memory consolidation. Nonetheless, a subthreshold dose of AM251 (120 ng/rat) reversed the amnesia induced by ACPA (0.006 µg/rat) and RS23597 (0.01 µg/rat). None of the above doses altered the locomotor activity. In conclusion, our results suggest that the NAc-shell 5-HT4 receptors are involved in the modulation of ACPA-induced amnesia.

• Authors: Ebrahim Khodayar, Shahrbanoo Oryan, Mohammad Nasehi, Mohammad-Reza Zarrindast
• Journal: Behavioural pharmacology (Behav Pharmacol) Vol. 27 Issue 1 Pg. 12-21 (Feb 2016) ISSN: 1473-5849 [Electronic] England
• PMID: 26340366 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aniline Compounds
• Arachidonic Acids
• Cannabinoid Receptor Antagonists
• Cnr1 protein, rat
• Nootropic Agents
• Piperidines
• Pyrazoles
• Receptor, Cannabinoid, CB1
• Serotonin 5-HT4 Receptor Agonists
• arachidonylcyclopropylamide
• Receptors, Serotonin, 5-HT4
• RS 67333
• AM 251

Topics

• Aniline Compounds (pharmacology)
• Animals
• Arachidonic Acids
• Cannabinoid Receptor Antagonists (pharmacology)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Emotions (drug effects, physiology)
• Male
• Maze Learning (drug effects, physiology)
• Memory Consolidation (drug effects, physiology)
• Memory Disorders (drug therapy, metabolism)
• Motor Activity (drug effects, physiology)
• Nootropic Agents (pharmacology)
• Nucleus Accumbens (drug effects, metabolism)
• Piperidines (pharmacology)
• Pyrazoles (pharmacology)
• Random Allocation
• Rats, Wistar
• Receptor, Cannabinoid, CB1 (antagonists & inhibitors, metabolism)
• Receptors, Serotonin, 5-HT4 (metabolism)
• Serotonin 5-HT4 Receptor Agonists (pharmacology)