Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS.

Abstract

Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In the present study, we established a lung metastasis animal model of CCS and investigated the therapeutic effect of boron neutron capture therapy (BNCT) using p-borono-L-phenylalanine (L-BPA). Biodistribution data revealed tumor-selective accumulation of (10)B. Unlike conventional gamma-ray irradiation, BNCT significantly suppressed tumor growth without damaging normal tissues, suggesting that it may be a potential new therapeutic option to treat CCS lung metastases.

• Authors: Tooru Andoh, Takuya Fujimoto, Minoru Suzuki, Tamotsu Sudo, Yoshinori Sakurai, Hiroki Tanaka, Ikuo Fujita, Naomasa Fukase, Hiroshi Moritake, Tohru Sugimoto, Toshiko Sakuma, Hiroshi Sasai, Teruya Kawamoto, Mitsunori Kirihata, Yoshinobu Fukumori, Toshihiro Akisue, Koji Ono, Hideki Ichikawa
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 106 Pg. 195-201 (Dec 2015) ISSN: 1872-9800 [Electronic] England
• PMID: 26337135 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Topics

• Animals
• Boron Neutron Capture Therapy
• Disease Models, Animal
• Female
• Lung Neoplasms (secondary)
• Mice
• Mice, Inbred BALB C
• Sarcoma, Clear Cell (radiotherapy)