[CARDIOPROTFETIVE EFECTS OF NECROSTATIN-7 IN THE RAT MODEL OF PERMANENT CORONARY OCCLUSION].

Abstract

The cardioprotective effects of necroptosis inhibitor necrostatin-7 were studied in the rat model of permanent coronary occlusion. It was found that intraperitoneal injection of necrostatin-7 at a dose of 14.5 mg/kg 60 minutes prior to permanent left coronary artery occlusion reduced the amount of scar tissue and scar length in the left ventricle on the 21st day after surgery. In addition, pretreatment with necrostatin-7 resulted in decreased plasma level of N-terminal pro-brain natriuretic peptide, which points to the improvement in left ventricular function.

• Authors: Yu V Dmitriev, A A Karpov, A V Dracheva, S M Minasian, S G Chefu, L V Vasina, E A Demchenko, I M M Galagudza
• Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova (Ross Fiziol Zh Im I M Sechenova) Vol. 101 Issue 4 Pg. 408-14 (Apr 2015) ISSN: 0869-8139 [Print] Russia (Federation)
• PMID: 26336739 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Peptide Fragments
• Thiazoles
• necrostatin-7
• pro-brain natriuretic peptide (1-76)
• Natriuretic Peptide, Brain

Topics

• Animals
• Apoptosis (drug effects)
• Autophagy (drug effects)
• Cicatrix (pathology, prevention & control)
• Coronary Vessels (drug effects, pathology)
• Disease Models, Animal
• Heart Ventricles (drug effects, pathology)
• Male
• Myocardial Infarction (drug therapy, etiology, pathology)
• Natriuretic Peptide, Brain (blood)
• Peptide Fragments (blood)
• Rats, Wistar
• Thiazoles (administration & dosage, therapeutic use)
• Ventricular Remodeling (drug effects)