Managing hyperphosphatemia in patients with chronic kidney disease on dialysis with ferric citrate: latest evidence and clinical usefulness.

Abstract

Ferric citrate is a novel phosphate binder that allows the simultaneous treatment of hyperphosphatemia and iron deficiency in patients being treated for end-stage renal disease with hemodialysis (HD). Multiple clinical trials in HD patients have uniformly and consistently demonstrated the efficacy of the drug in controlling hyperphosphatemia with a good safety profile, leading the US Food and Drug Administration in 2014 to approve its use for that indication. A concurrent beneficial effect, while using ferric citrate as a phosphate binder, is its salutary effect in HD patients with iron deficiency being treated with an erythropoietin-stimulating agent (ESA) in restoring iron that becomes available for reversing chronic kidney disease (CKD)-related anemia. Ferric citrate has also been shown in several studies to diminish the need for intravenous iron treatment and to reduce the requirement for ESA. Ferric citrate is thus a preferred phosphate binder that helps resolve CKD-related mineral bone disease and iron-deficiency anemia.

• Authors: Yoram Yagil, Stephen Z Fadem, Kotagal S Kant, Udayan Bhatt, Mohammed Sika, Julia B Lewis, Dana Negoi, Collaborative Study Group
• Journal: Therapeutic advances in chronic disease (Ther Adv Chronic Dis) Vol. 6 Issue 5 Pg. 252-63 (Sep 2015) ISSN: 2040-6223 [Print] United States
• PMID: 26336594 (Publication Type: Journal Article, Review)