Abstract |
The emerging role of bone morphogenetic proteins (BMPs) in the initiation and progression of multiple cancers has drawn great attention in cancer research. In this study, we report that BMP-2 can promote the proliferation of the pancreatic tumor cell line, PANC-1. Secreted phosphoprotein 24 kD ( Spp24), a BMP binding protein, did not affect the proliferation of the cells but promoted the apoptosis of the cells in vitro. In a xeneograft tumor model using PANC-1 cells, BMP-2 dramatically promoted tumor growth, while Spp24 not only abolished the effect of BMP-2, but also dramatically induced tumor shrinking when used alone. Activation of Smad1/5/8 participated in this process as demonstrated by immunohistochemical staining of phosphorylated Smad 1/5/8. We conclude that Spp24 can be developed into a therapeutic agent that could be employed in clinical situations where the inhibition of BMPs and related proteins is advantageous.
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Authors | Chen-Shuang Li, Haijun Tian, Min Zou, Ke-Wei Zhao, Yawei Li, Lifeng Lao, Elsa J Brochmann, M Eugenia L Duarte, Michael D Daubs, Yan-Heng Zhou, Samuel S Murray, Jeffrey C Wang |
Journal | Biochemical and biophysical research communications
(Biochem Biophys Res Commun)
Vol. 466
Issue 2
Pg. 167-72
(Oct 16 2015)
ISSN: 1090-2104 [Electronic] United States |
PMID | 26334966
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- BMP2 protein, human
- Bone Morphogenetic Protein 2
- Phosphoproteins
- secreted phosphoprotein 24
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Topics |
- Apoptosis
- Bone Morphogenetic Protein 2
(physiology)
- Cell Line, Tumor
- Cell Proliferation
- Humans
- Pancreatic Neoplasms
(pathology)
- Phosphoproteins
(physiology)
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