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Atypical Clinical Presentation of a Newer Generation Anti-Fungal Drug-Resistant Fusarium Infection After a Modified Multi-Visceral Transplant.

Abstract
BACKGROUND Fusarium spp. infections have become an emerging and lethal threat to the immunocompromised patient population, especially those with neutropenia. Recently there have been increased reports in solid organ transplant recipients. Presentation is commonly as soft tissue infections several months post-transplant. With high morbidity and mortality, efficacious antifungal therapy is essential. This remains challenging with limited data and no established clinical breakpoints defined. CASE REPORT We report on a modified multi-visceral transplant patient that developed a Fusarium infection only 7 weeks post-transplant in the native hard palate and esophagus, without any soft tissue lesions, which persisted despite aggressive combination treatment with amphotericin B lipid complex and voriconazole. CONCLUSIONS Fusarium spp. infection in solid organ transplant is a significant challenge without clear diagnostic clinical indicators of infection, or specific time of onset, in addition to possible emergence of a more aggressive drug-resistant strain.
AuthorsAhmed Kandeel, Kareem Abu-Elmagd, Michael Spinner, Ajai Khanna, Koji Hashimoto, Masato Fujiki, Mansiur Parsi, Ana Bennett, Galal El-Gazzaz, Ahmed Abd-Elaal
JournalAnnals of transplantation (Ann Transplant) Vol. 20 Pg. 512-8 (Sep 03 2015) ISSN: 2329-0358 [Electronic] United States
PMID26334671 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antifungal Agents
  • liposomal amphotericin B
  • Amphotericin B
  • Voriconazole
Topics
  • Amphotericin B (therapeutic use)
  • Antifungal Agents (therapeutic use)
  • Drug Resistance, Fungal
  • Esophagus (transplantation)
  • Fatal Outcome
  • Female
  • Fusariosis (drug therapy, etiology)
  • Humans
  • Immunocompromised Host
  • Middle Aged
  • Organ Transplantation (adverse effects)
  • Palate, Hard (transplantation)
  • Treatment Failure
  • Voriconazole (therapeutic use)

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