Abstract | BACKGROUND: OBJECTIVE: METHOD: The rats were divided into two groups. The first group graded single doses of aminophylline from 100 to 300 mg/kg were administered intraperitoneally. On the basis of the results Aminophylline, a dose (300 mg/kg) producing tonic-clonic seizures and mortality in 100% animals was selected as control in the study. The second group were subjected to single antioxidant ( Vitamin E or Vitamin C) or in combination for 45 days then single doses of aminophylline 300 mg/kg administered intraperitoneally to rats. RESULT:
Aminophylline induced convulsions in rats in a dose-dependent manner, and both incidence of seizure and mortality were maximum at 300 mg/kg and there was significant increase of free radical generation. But though pre-treatment with antioxidants showed differential attenuating effects on aminophylline induced free radical generation as we all known but they were very much ineffective in antagonizing aminophylline induced seizures and post-seizure mortality by any appreciable extent. CONCLUSION:
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Authors | U K Roy, M Pal, S Datta, S Harlalka |
Journal | Kathmandu University medical journal (KUMJ)
(Kathmandu Univ Med J (KUMJ))
2014 Oct-Dec
Vol. 12
Issue 48
Pg. 269-74
ISSN: 1812-2078 [Electronic] Nepal |
PMID | 26333582
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Free Radical Scavengers
- Reactive Oxygen Species
- Aminophylline
- Ascorbic Acid
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Topics |
- Aminophylline
- Animals
- Antioxidants
(pharmacology)
- Ascorbic Acid
(pharmacology)
- Dose-Response Relationship, Drug
- Female
- Free Radical Scavengers
(pharmacology)
- Male
- Oxidative Stress
- Rats
- Rats, Wistar
- Reactive Oxygen Species
- Seizures
(chemically induced, prevention & control)
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