Abstract |
Mitochondrial DNA ( mtDNA) deletions are found in many diseased tissues and lead to impairment of mitochondrial functions. In this study, we found wide presence of the common 4977-bp and a novel 4408-bp deletion in the mtDNA of mesenteric arteries from patients with colorectal cancer. These two deletions were also detected in samples from healthy individuals. The content of mtDNA with the 4977-bp deletion was significantly lower in healthy controls than cancer-associated samples, and there was no significant difference for the 4408-bp deletion between the two groups. These results suggest that mtDNA in blood vessels around cancer cells may be strongly affected by oxidative stress and tend to accumulate more large-scale variations.
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Authors | Tao Li, Gui-Lan Chen, Huan Lan, Liang Mao, Bo Zeng |
Journal | Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis
(Mitochondrial DNA A DNA Mapp Seq Anal)
Vol. 27
Issue 5
Pg. 3774-6
(09 2016)
ISSN: 2470-1408 [Electronic] England |
PMID | 26332461
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Base Sequence
- Case-Control Studies
- Colorectal Neoplasms
(epidemiology, genetics)
- DNA Mutational Analysis
- DNA, Mitochondrial
(genetics)
- Humans
- Mesenteric Arteries
(pathology)
- Middle Aged
- Prevalence
- Sequence Deletion
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