Abstract | UNLABELLED: TREM2 and TYROBP are causal genes for Nasu-Hakola disease (NHD), a rare autosomal recessive disease characterized by bone lesions and early-onset progressive dementia. TREM2 forms a receptor signaling complex with TYROBP, which triggers the activation of immune responses in macrophages and dendritic cells, and the functional polymorphism of TREM2 is reported to be associated with neurodegenerative disorders such as Alzheimer's disease (AD). The objective of this study was to reveal the involvement of TYROBP and TREM2 in the pathophysiology of AD and schizophrenia. METHODS: We investigated the mRNA expression level of the 2 genes in leukocytes of 26 patients with AD and 24 with schizophrenia in comparison with age-matched controls. Moreover, we performed gene association analysis between these 2 genes and schizophrenia. RESULTS: No differences were found in TYROBP mRNA expression in patients with AD and schizophrenia; however, TREM2 mRNA expression was increased in patients with AD and schizophrenia compared with controls (P < 0.001). There were no genetic associations of either gene with schizophrenia in Japanese patients. CONCLUSION:
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Authors | Yoko Mori, Yuta Yoshino, Shinichiro Ochi, Kiyohiro Yamazaki, Kentaro Kawabe, Masao Abe, Tomoji Kitano, Yuki Ozaki, Taku Yoshida, Shusuke Numata, Takaaki Mori, Junichi Iga, Norio Kuroda, Tetsuro Ohmori, Shu-Ichi Ueno |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 9
Pg. e0136835
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 26332043
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Membrane Glycoproteins
- RNA, Messenger
- Receptors, Immunologic
- TREM2 protein, human
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Topics |
- Aged
- Aged, 80 and over
- Alzheimer Disease
(genetics)
- Female
- Humans
- Leukocytes
(metabolism)
- Lipodystrophy
(genetics)
- Male
- Membrane Glycoproteins
(genetics)
- Osteochondrodysplasias
(genetics)
- Polymorphism, Single Nucleotide
- RNA, Messenger
(genetics)
- Receptors, Immunologic
(genetics)
- Schizophrenia
(genetics)
- Subacute Sclerosing Panencephalitis
(genetics)
- Up-Regulation
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