Glucose-6-phosphate dehydrogenase expression is correlated with poor clinical prognosis in esophageal squamous cell carcinoma.

Abstract	Increasing evidence has demonstrated that glucose-6-phosphate dehydrogenase (G6PD), a key metabolic enzyme, participating in pentose phosphate pathway (PPP), is tightly associated with development and progression of a variety of tumors. Here, we reported expression of G6PD and its association with the prognosis of the patients with esophageal squamous cell carcinoma (ESCC). The results revealed significantly elevated G6PD mRNA and protein expressions in ESCC tissues compared with normal tissues (P < 0.05). Furthermore, high G6PD expression was tightly associated with histological grade, TNM staging and lymph node metastasis (P < 0.05), but not related to the patients' age and gender (P > 0.05). Importantly, the survival time of G6PD-positive patients was markedly lower than that of G6PD-negative patients (P < 0.05). Most notably, Cox multivariate assay demonstrated that G6PD was an independent prognostic factor for the patients with ESCC. In conclusion, G6PD may be a novel predictor for the prognosis of the patients with ESCC.
Authors	Xin Wang, XiaoJuan Li, XiaQing Zhang, RuiTai Fan, Hao Gu, YongGang Shi, HongTao Liu
Journal	European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (Eur J Surg Oncol) Vol. 41 Issue 10 Pg. 1293-9 (Oct 2015) ISSN: 1532-2157 [Electronic] England
PMID	26329784 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	Copyright © 2015 Elsevier Ltd. All rights reserved.
Chemical References	RNA, Messenger Glucosephosphate Dehydrogenase
Topics	Blotting, Western Carcinoma, Squamous Cell (enzymology, mortality, pathology) Disease Progression Esophageal Neoplasms (enzymology, mortality, pathology) Esophageal Squamous Cell Carcinoma Esophagus (metabolism, pathology) Female Gene Expression Regulation, Neoplastic Glucosephosphate Dehydrogenase (genetics, metabolism) Humans Immunohistochemistry Lymph Nodes (pathology) Lymphatic Metastasis Male Middle Aged Neoplasm Grading Neoplasm Staging Prognosis RNA, Messenger (metabolism) Reverse Transcriptase Polymerase Chain Reaction

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