Abstract | BACKGROUND: OBJECTIVE: We sought to perform a systematic review and meta-analysis to estimate this prevalence more precisely and to identify patients who need substitution treatment. METHODS: RESULTS: The meta-analysis revealed a prevalence of pooled IgG, IgA, and IgM deficiencies in 13% of patients with recurrent CRS and 23% of patients with difficult-to-treat CRS. The prevalence of IgG subclass deficiency (5% to 50%) and specific antibody deficiency (8% to 34%) was increased in patients with CRS, as was the prevalence of respiratory allergies in patients with recurrent CRS (31% to 72%). CONCLUSION:
Immunoglobulin deficiency is a frequent condition in patients with CRS. An even higher prevalence of atopy was observed in patients with recurrent CRS. Therefore immunoglobulin titers and accurate allergy diagnostic workups are strongly recommended in these patients to provide specific treatments for symptom alleviation. However, there is a need for larger prospective studies addressing the effect of specific therapeutic interventions for CRS.
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Authors | Adrien J-P Schwitzguébel, Peter Jandus, Jean-Silvain Lacroix, Jörg D Seebach, Thomas Harr |
Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 136
Issue 6
Pg. 1523-1531
(Dec 2015)
ISSN: 1097-6825 [Electronic] United States |
PMID | 26329513
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Copyright | Copyright © 2015 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved. |
Topics |
- Chronic Disease
- Comorbidity
- Dysgammaglobulinemia
(epidemiology)
- Humans
- Prevalence
- Rhinitis
(epidemiology)
- Sinusitis
(epidemiology)
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