AST-120 (
kremezin) exhibits its favourable effects in reducing the levels of renal toxins by selective adsorption of low molecular weight substances from the intestinal lumen. So far, a vast majority of studies were focused on the role of
AST-120 in the treatment of
chronic kidney diseases and cardiovascular disorders, and positive
therapeutic effects of the agent have already been confirmed in clinical conditions. Up to the present, there are only a few studies regarding the role of
AST-120 in
irritable bowel syndrome (IBS). Compelling data suggest the ability of the compound to adsorb
protein-bound
uremic toxins and mast cell derived mediators and to modulate the farnesoid X receptor, which is a
bile acid sensor indispensable for maintaining homeostasis in the intestine. In this review we focus on the actions of
AST-120 on intestinal permeability, reduction of visceral sensitivity and alteration of gut motility. We also discuss whether
AST-120 can mitigate common IBS symptoms, such as
abdominal pain, bloating and malfunction of the colonic transit and thus improve the quality of life of patients with IBS.