Synthesis and anticonvulsant activity of N-phthaloyl GABA--a new GABA derivative.

Abstract

A new gamma-aminobutyric acid derivative, N-phthaloyl GABA (P-GABA), was synthesised and its anticonvulsant activity was tested and compared with sodium valproate for efficacy against experimentally induced convulsions in mice. At a dose of 80 mg/kg, P-GABA rendered more protection than sodium valproate. ED50 of P-GABA and sodium valproate against bicuculline-induced convulsion was 96 and 301 mg/kg respectively in mice.

• Authors: S Bhowmick, M Pal, S P Pal
• Journal: Indian journal of experimental biology (Indian J Exp Biol) Vol. 27 Issue 9 Pg. 805-8 (Sep 1989) ISSN: 0019-5189 [Print] India
• PMID: 2632400 (Publication Type: Journal Article)

Chemical References

• Anticonvulsants
• N-phthaloyl-4-aminobutyric acid
• gamma-Aminobutyric Acid

Topics

• Animals
• Anticonvulsants
• Locomotion
• Male
• Mice
• Muscle Relaxation
• Rabbits
• Seizures (drug therapy, mortality)
• gamma-Aminobutyric Acid (analogs & derivatives, pharmacology)