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Darunavir: A Review in Pediatric HIV-1 Infection.

Abstract
Darunavir (Prezista®), administered in combination with ritonavir and background antiretroviral therapy, is approved in the USA and the EU for the treatment of HIV-1 infection in pediatric patients aged ≥3 years. Ritonavir-boosted darunavir provided effective virologic suppression in treatment-naïve adolescents with HIV-1 infection, according to the results of the noncomparative, phase II DIONE trial. Ritonavir-boosted darunavir also had sustained efficacy in treatment-experienced children and/or adolescents with HIV-1 infection, according to the results of the noncomparative, phase II DELPHI and ARIEL trials. Ritonavir-boosted darunavir was generally well tolerated in pediatric patients with HIV-1 infection. Although more data are needed in pediatric populations (particularly data comparing darunavir with other antiretroviral agents), ritonavir-boosted darunavir is an important option for the treatment of pediatric patients with HIV-1 infection.
AuthorsGillian M Keating
JournalPaediatric drugs (Paediatr Drugs) Vol. 17 Issue 5 Pg. 411-21 (Oct 2015) ISSN: 1179-2019 [Electronic] Switzerland
PMID26323490 (Publication Type: Journal Article, Review)
Chemical References
  • Anti-Retroviral Agents
  • HIV Protease Inhibitors
  • Darunavir
Topics
  • Anti-Retroviral Agents (therapeutic use)
  • Child
  • Darunavir (adverse effects, pharmacokinetics, pharmacology, therapeutic use)
  • HIV Infections (drug therapy)
  • HIV Protease Inhibitors (adverse effects, pharmacokinetics, pharmacology, therapeutic use)
  • HIV-1
  • Humans

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