[Comparison of clinical characteristics and laboratory parameters of patients with dermatomyositis-specific autoantibodies and autoantibody-negative patients].

Abstract

INTRODUCTION:

Myositis is an autoimmune disease characterised by proximal muscle weakness.

AIM:

The aim of the authors was to determine the frequency of dermatomyositis-specific autoantibodies (anti-Mi-2, anti-transcriptional intermediary factor 1 gamma, anti-nuclear matrix protein 2, anti-small ubiquitin-like modifier activating enzyme, anti-melanoma differentiation-associated gene) in a Hungarian myositis population and to compare the clinical features with the characteristics of patients without myositis-specific antibodies.

METHOD:

Antibodies were detected using immunoblot and immunoprecipitation.

RESULTS:

Of the 330 patients with myositis, 48 patients showed dermatomyositis-specific antibody positivity. The frequency of antibodies in these patients was lower than those published in literature Retrospective analysis of clinical findings and medical history revealed that patients with dermatomyositis-specific autoantibody had more severe muscle weakness and severe skin lesions at the beginning of the disease.

CONCLUSIONS:

Antibodies seem to be useful markers for distinct clinical subsets, for predicting the prognosis of myositis and the effectiveness of the therapy.

• Authors: Levente Bodoki, Dóra Budai, Melinda Nagy-Vincze, Zoltán Griger, Zoe Betteridge, Katalin Dankó
• Journal: Orvosi hetilap (Orv Hetil) Vol. 156 Issue 36 Pg. 1451-9 (Sep 06 2015) ISSN: 0030-6002 [Print] Hungary
• Vernacular Title: Dermatomyositis-specifikus autoantitesttel rendelkező és autoantitest-negatív betegeink klinikai jellemzőinek és laboratóriumi paramétereinek összehasonlítása.
• PMID: 26320599 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Autoantibodies
• Mi-2 antibodies

Topics

• Adult
• Autoantibodies (blood)
• Dermatomyositis (complications, immunology, physiopathology)
• Female
• Humans
• Immunoblotting
• Immunoprecipitation
• Male
• Middle Aged
• Muscle Weakness (immunology)
• Retrospective Studies
• Treatment Outcome