Increase in Dickkopf-1 Serum Level in Recent Spondyloarthritis. Data from the DESIR Cohort.

Abstract

OBJECTIVES:

To investigate DKK-1 and SOST serum levels among patients with recent inflammatory back pain (IBP) fulfilling ASAS criteria for SpA and associated factors.

METHODS:

The DESIR cohort is a prospective, multicenter French cohort of 708 patients with early IBP (duration >3 months and <3 years) suggestive of AxSpA. DKK-1 and SOST serum levels were assessed at baseline and were compared between the subgroup of patients fulfilling ASAS criteria for SpA (n = 486; 68.6%) and 80 healthy controls.

RESULTS:

Mean SOST serum levels were lower in ASAS+ patients than healthy controls (49.21 ± 25.9 vs. 87.8 ± 26 pmol/L; p<0.0001). In multivariate analysis, age (p = 5.4 10-9), CRP level (p<0.0001) and serum DKK-1 level (p = 0.001) were associated with SOST level. Mean DKK-1 serum levels were higher in axial SpA patients than controls (30.03 ± 15.5 vs. 11.6 ± 4.2 pmol/L; p<0.0001). In multivariate analysis, DKK-1 serum levels were associated with male gender (p = 0.03), CRP level (p = 0.006), SOST serum level (p = 0.002) and presence of sacroiliitis on radiography (p = 0.05). Genetic association testing of 10 SNPs encompassing the DKK-1 locus failed to demonstrate a significant contribution of genetics to control of DKK-1 serum levels.

CONCLUSIONS:

DKK-1 serum levels were increased and SOST levels were decreased among a large cohort of patients with early axial SpA compared to healthy controls. DKK-1 serum levels were mostly associated with biological inflammation and SOST serum levels.

• Authors: Gaetane Nocturne, Stephan Pavy, Saida Boudaoud, Raphaèle Seror, Philippe Goupille, Philippe Chanson, Désirée van der Heijde, Floris van Gaalen, Francis Berenbaum, Xavier Mariette, Karine Briot, Antoine Feydy, Pascal Claudepierre, Philippe Dieudé, Joanne Nithitham, Kimberly E Taylor, Lindsey A Criswell, Maxime Dougados, Christian Roux, Corinne Miceli-Richard
• Journal: PloS one (PLoS One) Vol. 10 Issue 8 Pg. e0134974 ( 2015) ISSN: 1932-6203 [Electronic] United States
• PMID: 26313358 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Adaptor Proteins, Signal Transducing
• Bone Morphogenetic Proteins
• DKK1 protein, human
• Genetic Markers
• Intercellular Signaling Peptides and Proteins
• SOST protein, human

Topics

• Adaptor Proteins, Signal Transducing
• Adult
• Back Pain (blood)
• Bone Morphogenetic Proteins (blood)
• Cohort Studies
• Cross-Sectional Studies
• Female
• France
• Genetic Markers
• Genotype
• Humans
• Intercellular Signaling Peptides and Proteins (blood, genetics)
• Male
• Polymorphism, Single Nucleotide
• Spondylarthritis (blood)
• Wnt Signaling Pathway