[Interaction of neuroblastoma C 1300 N18 cells with liposomes and intermembrane metabolism of lipids].

Abstract

The methods of isotopic and fluorescent labels have shown that interaction of cells of neuroblastoma S 1300 N 18 with small one-layer neutral liposomes prepared of the egg phosphatidyl choline with the addition of different amounts of cholesterol is realized by two mechanisms: the transmembrane transfer of cholesterol by the concentration gradient and membrane lipid metabolism proper, the ratios of cholesterol phospholipids in the biological and artificial membranes being equal. A dependence is established of the neuroblastoma cell viability on the activity of the cholesterol membrane metabolism. A problem on the mechanism which causes the death of cells during the interaction with phosphatidyl-cholesterol liposomes is under discussion.

• Authors: G L Volkov, N M Gula, N M Govseieva, I P Artemenko, O F Perederiĭ, O A Khomutovs'kiĭ
• Journal: Ukrainskii biokhimicheskii zhurnal (1978) (Ukr Biokhim Zh (1978)) 1989 Nov-Dec Vol. 61 Issue 6 Pg. 69-75 ISSN: 0201-8470 [Print] Ukraine
• Vernacular Title: Vzaiemodiia klitin neĭroblastomi C 1300 N18 iz liposomami ta mizhmembranniĭ obmen lipidiv.
• PMID: 2631322 (Publication Type: English Abstract, Journal Article)

Chemical References

• Liposomes
• Membrane Lipids
• Cholesterol

Topics

• Biological Transport
• Cell Survival
• Cholesterol (metabolism)
• Humans
• Liposomes (metabolism)
• Membrane Lipids (metabolism)
• Neuroblastoma (metabolism, pathology)
• Tumor Cells, Cultured (metabolism, pathology)