Abstract | OBJECTIVE: Intrathecal (IT) morphine improves pain control and decreases opioid requirements in children following thoracic and abdominal surgery. However, studies in children report variable durations of analgesia following IT morphine. The purpose of this study is to describe the duration of analgesia in children undergoing surgical correction of idiopathic scoliosis. DESIGN: Retrospective chart review. SETTING: Pediatric hospital within a tertiary care academic medical center. PARTICIPANTS: MAIN OUTCOME MEASURE(S): RESULTS: Mean opioid exposure was significantly increased during the 13-24-hour compared to the 0-12-hour time period (23.0 ± 12.5 mg parenteral morphine vs 15.9 ± 1.7 mg; p = 0.0006). The only factors significantly associated with morphine exposure during the 0-12-hour period included the median pain score (0-12 hours) (odds ratio [OR], 1.92; 95% confidence interval [CI], 0.033-3.80; p = 0.046) and total acetaminophen dose (OR, 0.003; 95% CI, 0.0008-0.005; p = 0.011). CONCLUSIONS:
|
Authors | Bethany W Ibach, Carol Loeber, Mohanad Shukry, Tracy M Hagemann, Donald Harrison, Peter N Johnson |
Journal | Journal of opioid management
(J Opioid Manag)
2015 Jul-Aug
Vol. 11
Issue 4
Pg. 295-303
ISSN: 1551-7489 [Print] United States |
PMID | 26312956
(Publication Type: Journal Article, Observational Study)
|
Chemical References |
- Analgesics, Non-Narcotic
- Analgesics, Opioid
- Acetaminophen
- Morphine
|
Topics |
- Acetaminophen
(administration & dosage)
- Adolescent
- Analgesics, Non-Narcotic
(administration & dosage)
- Analgesics, Opioid
(administration & dosage, pharmacokinetics)
- Child
- Drug Administration Schedule
- Drug Therapy, Combination
(methods)
- Female
- Humans
- Injections, Spinal
(methods)
- Male
- Morphine
(administration & dosage, pharmacokinetics)
- Pain Management
(methods)
- Pain Measurement
- Pain, Postoperative
(diagnosis, drug therapy)
- Retrospective Studies
- Scoliosis
(surgery)
- Spinal Fusion
(adverse effects, methods)
- Time Factors
- Treatment Outcome
- United States
|